Nucleotides are the basic building blocks of DNA. They consist of nitrogenous base + pentose sugar + phosphate groups which provide us with special functional roles. IMUREGEN contains Nucleotides that supports our DNA/RNA.
Your NUCLEOTIDES are like the parts of a zipper; they should perfectly match or it will not work. A research on how the body repairs a DNA when damaged won Nobel Prize in Chemistry 2015.
The mechanism of repair:
1. Base Excision Repair
2. Nucleotide Excision Repair
3. Mismatch Repair
Where do nucleotides come from?
Nucleotides are present in the food we eat and with science, we are able to extract this important nutrient without having to eat high amounts of meat. Dietary nucleotides, as their name implies, come from our diets. These are termed exogenous since they are created external to our body from various food sources.
Nucleotides are some of the largest molecules synthesized by our cells, and their creation requires many substrates, many steps and huge amounts of energy. They biosynthesis of nucleotides is under very tight control since energy is wasted when making too much, and DNA replication and cellular metabolism is slowed down when making too little. Our cells are also very sensitive to the number of free nucleotides floating within the nucleus or the cytoplasm.
The cell will always choose to use the nucleotides that have already been created before synthesizing new ones. Cellular energy is conserved and DNA replication is enhanced by making sure that your cells are constantly supplied with exogenous nucleotides. Our body can also create nucleotides. These are referred to as endogenous since they are created within. The creation of new nucleotides is referred to as “de novo synthesis”.
Nearly all types of foods provide a source of nucleotides. In general, you should consume adequate nucleotides regardless of the specific foods that make up your diet but this may be difficult for some who has an intestinal problem, where nutrient are inefficiently absorbed. IMUREGEN that promotes gut integrityprovides the nucleotides our body needs, using nano-technology that the body is able to absorb. IMUREGEN Food Supplement is able to regenerate intestinal villi, that help with nutrient absorption.
Dietary sources of nucleotides:
ADENINE / GUANINE
042 / 047
015 / 016
012 / 012
059 / 077
072 / 078
032 / 041
008 / 185
014 / 024
011 / 026
026 / 080
006 / 118
018 / 015
017 / 014
088 / 074
054 / 051
104 / 082
046 / 039
TOTAL PURINES / RNA
213 / 134
171 / 049
162 / 061
289 / 259
243 / 402
223 / 187
411 / 341
136 / 085
194 / 203
250 / 289
245 / 243
135 / 100
056 / 356
195 / 173
162 / 140
222 / 306
144 / 485
The scientific role of Nucleotides in our body:
1. They are important components of nucleic acids (DNA, RNA)
2. Carriers of chemical energy in the cell (eg., ATP, GTP)
3. Components of cofactors (eg., NAD, FAD)
4. Intermediates in cellular communication and signal transduction (eg., cAMP, cGMP)
5. Donor substrates for glycobiology (eg. UDPG).
Nucleotides are ubiquitous compounds in the cells of all living organisms and play a critical role in many biological processes. They are found in all cells and nuclei that are formed after the cleavage (cell division) of nucleic acids. They are the building blocks of nucleic acids DNA and RNA, which are bearers of heredity. They are also part of many important enzymes necessary for nutrition and energy metabolism.
Nucleotides in DNA
Nucleotides which form part of the DNA is like the mobile phone’s OS (operating system). If the phone is infected with a virus, the OS may malfunctions. The easiest way is to reboot the phone’s OS (start from the beginning) and the phone will work back as intended by tapping its original design or code and applying the sequence for the phone to work well again.
Another example is a photocopier. Our DNA is the original copy or design. It can make copies of itself (photocopy). When the photocopies are damaged, we can go back to the original copy (DNA) and replicated itself again. Therefore, it is important to maintain the integrity of the original design (DNA). We can protect our cells (organs) at DNA structure through nucleotides supplementation.
Important function of the Nucleotides in the cell
1. They carry the energy needed by each cell.
2. Nucleotides store genetic information; specific sequences of nucleotides make up genes that help to guide your cells’ behavior.
3. The nucleotides in RNA contribute to multiple steps in protein generation within your cells. Since the proteins made partially as a result of nucleotides make up the structure and function of your cells, nucleotides prove important for maintaining cell and tissue health. An inability to generate new DNA and RNA, due to a lack of available nucleotides, can lead to tissue damage and disease.
Why our body needs nucleotides supplement
The food which has support all physiological functions must be represented in adequate proportions of low molecular substance (trace elements, minerals, vitamins, etc.), And high molecular weight substances (carbohydrates, lipids, proteins). Only in the period of growth and aging, exhaustion or diseases are some components of priority (increase intake of certain trace elements, vitamins, and proteins), sometimes restricted (carbohydrates and saturated lipids).
It turned out that it is under the above circumstances rising requirements of the organism to some other low molecular weight substances, which are indeed present in the normal diet, but not in sufficient quantities. They are mainly nucleotides.
Dividing cells in the human body need nucleotide. From this data, we can deduce how many nucleotides in an organism is only required for cell division in quiescent tissue regeneration, restoration of skin, mucosal epithelium, and hematopoiesis. Previously experts thought that the body can generate enough of them even in case of increased needs, but it turned out that it is necessary to supply extra food.
It is, therefore, necessary to ensure their intake during childhood growth of the organism, in adulthood and old age for tissue regeneration, during convalescence after illness or surgery, especially for a full course of the immune response. It is appropriate to increase their income as a precaution during the expected epidemic of infectious diseases.
Nucleotides are also ‘materials’ or proteins that existing stem cells in our body needs to repair itself.
Nutrition and Immunity
Interconnection terms nutrition and immunity is particularly recently the subject of basic research. It turns out that lifestyle changes in recent decades, including changes in nutritional status, has an impact on a number of diseases that are mediated by immune responses.
Disease resistance and quality and length of human life rest on three pillars: mental stability, reasonable and adequate physical activity and a balanced diet (nutrition). Over the past 150 years was extended in industrialized countries, life expectancy, mainly due to the introduction of public health measures in the 19th century, having resulted in the spread of the deadliest pandemics and epidemics of infectious diseases, and in no small part thanks to the discovery of effective drugs such as chemotherapeutics and antibiotics.
However, at least since the middle of last century, began professional and the general public to realize that lifestyle in these countries brings the negatives: the declining population immunity to infectious diseases and an increase in allergic, autoimmune, cardiovascular, neurodegenerative diseases and cancer.
The inversely related to the aforementioned triad: the ever-increasing trend of engagement work is accompanied by increased mental stress, lack of time for active relaxation (physical activity) and changing eating habits (preference technologically modified food), which is often compensated by increased consumption of food products and support Finally drugs.
The Paleolithic diet
Genes regulating metabolic functions of the human body have evolved over millions of years and are still adapted to the way of feeding our prehistoric ancestors. Eating habits fundamental changes accompanying the modern lifestyle may not always be in conformity with genetically given metabolism.
Types of food from the Paleolithic hunter-gatherer society has changed dramatically. It is estimated that our ancestors’ diet contained over current our diet 1015 times more fiber, 510 times more n3 polyunsaturated fatty acids and antioxidants, and 3 times more protein and potassium salts. In contrast, today receives 10 to 20 times more of sodium chloride and at least 4 times more saturated and 2 times more monounsaturated fatty acids.
To this must be added the consumption of “high energy” but “nutritionally empty” food and lack of exercise. The consumption of fats has increased from 20% in the 19th century to today 50%, at the expense of “low energy diet”, whose intake decreased over the same period by half.
Mutual relations of the immune system and nutritional components are essential for growth, development, and health of the individual. The role of nucleotides in the prevention and immunity
Twenty years ago, noted the symposium the American Society for Nutrition, that is the biochemical or physiological reason for it to be nutritionally nucleotides considered essential because in nitrogen metabolism play a negligible role.
New research yielded an unambiguous demonstration that the nucleotides are important from many points of view indispensable nutritional component. The organism is a food can be used directly, without having to construct high energy “de novo synthesis*”. Their insufficient food intake may result from not only Larger variability range of immune functions but mainly reflected in the function of the liver, heart, and intestinal tract. In childhood, then delays the development of the CNS, immune system and overall growth.
* The creation of new nucleotides is referred to as “de novo synthesis”